Copy the folder inside the extracted CCAV17 directory (Cookie-ClickerV17) and place it into "C:\Program Files (x86)\Steam\steamapps\common\Cookie Clicker\resources\app\mods\local",
If a previous version of the mod is present in this folder, delete it before launching the game,
Launch the game. You should hear your NVDA announce "NVDA accessibility mod loaded successfully",
You may use NVDA's built in keystrokes for navigating elements (primarily the arrow keys, H and K) to explore the game and begin your playthrough. You will rely on these keystrokes to perform the majority of in-game actions,